Endocrine Abstracts

Background: Radiotherapy (RT) with or without chemotherapy is a common treatment for head and neck squamous cell carcinoma (HNSCC) patients and it can cause adverse effects, including dysfunctions of thyroid. The aim of this study was to identify thyroid dysfunction among patients submitted to external RT for treatment of HNSCC, with serial evaluation of thyroid function.Material and methods: This is a retrospective longitudinal study of the follow-up of...

Introduction: Knowing mental representations about the phenomenon of illness and medical care allows the clinical team to have better emotional handling of their patients, with gains in greater adherence to treatments. Graves’ Ophthalmopathy is an inflammatory disease with primary involvement of the extraocular muscles and orbit, being the most frequent extrathyroidal manifestation of Graves’ disease (GD). Many patients have psychological status changes even after su...

Objectives: MCL-1 and PD-L1 proteins are related to carcinogenesis mechanisms in differentiated thyroid carcinoma (DTC). Tumor antigens stimulate the expression of PD-1 in immune cells, which binds to PD-L1 of tumor cells, inducing immune escape from the tumor. MCL-1, an anti-apoptotic member of the BCL-2 family and has a high oncogenic potential. The relationship of these markers with prognosis in DTC remains unknown. We aim to evaluate the clinical utility of immunohistochem...

Objectives: BRAFV600E mutation is present in 50% of aggressive papillary thyroid carcinoma(PTC). TERT promoter (pTERT) mutations (C228T, C250T) are related to cancer growth and reduced overall- and disease-free survivals in differentiated thyroid carcinomas(DTC). We report a patient with an extremely aggressive PTC presenting in the primary lesion two pTERT mutations (C228T and C250T), and absence of BRAFV600E.<p class="abstext"...